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Three myths about sebum - a scientific perspective
There is a lot of information and myths about sebum that can easily confuse us about its main functions and its actual role in our skin health. It's also not uncommon for the available information to be contradictory, making it even more difficult to understand how we should think about our skin care routines. In this article, we take a closer look at the main functions of sebum for skin health and explore the main truths and myths from a scientific point of view.

What is sebum and do we really need it?

Sebum is a complex mixture of lipids produced by the sebaceous glands, an important endocrine organ* located in the dermis of the skin. The main functions of sebum are believed to be protection against water loss, important for natural hydration of the skin and antimicrobial protection. Now that we've discussed the important role of sebum, it's time to review some key misconceptions and truths about sebum.

Sebum leads to oily skin.

It is important to stress out that the existence of sebum alone does not equal oily skin condition; however, situations, when oversized sebaceous glands produce excessive amounts of sebum, can lead to oily skin appearance. While there is no clear explanation why some users are more prone to sebum over-production than others, we would like to note some factors which are believed to increase the risk for oily skin development.

Enligt forskarna Endly och Miller (2017) är män mer benägna att producera mer talg på grund av högre testosteronnivåer i kroppen. Men det kan faktiskt vara ganska bra att ha mer talgproduktion. Den skyddar huden från att torka ut, och män som normalt har fetare hud jämfört med kvinnor har mindre problem med torr hud och känslighet.

The hormonal aspect of sebum production is an interesting phenomenon, where the sebum production reduces with age as hormone levels also decrease. Several studies also report that sebum production levels can vary depending on different environments and seasons, for example, it can be higher in summer and spring seasons as well as in more humid environments. Diet is another significant factor to take into consideration. We would like to refer to the research that was developed scientist Fulton and his team, during which 5 male volunteers ingested two chocolate bars daily for one month period. Although researchers did not conclude a significant correlation between fat and sebum production, at the end of the experiment the collected sebum increase was observed in 3 of 5 volunteers, indicating that food might influence sebaceous gland production processes. Furthermore, clinical studies also suggest that certain product classes such as milk and dairy products, saturated fats, and hyperglycemic carbohydrates have an impact on acne development, and hence vegetable and fish product rich diets adoption is recommended.

Sebum is responsible for different skin condition development, such as acne.

Situations, when sebaceous glands are over-stimulated and produce more sebum than pores can handle can indeed result in different skin condition development, such as previously mentioned skin oiliness, blocked pores, and can ultimately lead to acne breakouts. If undesirable skin conditions develop, the sebum overproduction can be tamed by applying cosmetic products that contain ingredients such as niacinamide, zinc, or organic acids. Study developed by Andrade and the research group (2018) showed how active ingredient application impacts acne-prone skin. During their study, a cosmetic formulation (consisting of niacinamide, pyridoxine tris-hexyldecanoate, and zinc-PCA) was applied over 6 weeks period, twice a day on 16 study participants' skin (forehead, malar, and chin regions) resulting in 60% acne lesion reduction; nevertheless, applied products did not reduce the skin barrier functions.

Furthermore, estrogen and vitamin A have also illustrated positive results in controlling sebum production. Before reviewing sebum care friendly ingredients from the Skinome product line, we would like to emphasize that each person’s skin case is unique, and therefore all skin condition treatment approaches must be discussed and carefully assessed with clinicians before adapting them.

Skinome's products contain previously mentioned ingredients that support the skin in controlling sebum production, for example, the organic lactobionic acid or so-called PHA acid is found in Skinome's Light emulsion and Night Active Control. Niacinamide which is a form of vitamin B3 is also found in several of our products, such as Light emulsion, Mineral cleanser, Night Active, Night active Retinol, and it has been shown to be an effective ingredient in improving barrier functions, reducing wrinkles and sebum production, hyperpigmentation control and a general improvement for acne skin. Finally, Zinc Ascorbate (vitamin C) and Zinc PCA, known for their antimicrobial and antioxidant properties, are included in our Night Active and Night Active Retinol products as well as in Rich emulsion.

It is a common myth that you need to remove sebum.

Although over washing and aggressive cleansing at first might seem like an intuitive step for removing the excess sebum, research data shows that this might remove lipids from the outermost layer of the skin, resulting in excessive skin drying, and hence significantly impact the barrier functions that lipids ensure for the skin. The research studies with animal models have shown the link between skin and fur abnormalities and certain surface lipid pathway disruption. For instance, one study reported that melanocortin-5 receptor (MC5-R) KO resulted in severe defects in water repulsion and thermoregulation due to decreased production of sebaceous lipids. To sum up, sebum is vital for our skin defenses and aggressive skin treatment methods or cleansing can negatively influence skin condition and cause dryness, sensitivity or even rosacea.

Skinome products show improvements in acne-prone skin in a study from 2021.

If sebum is excessively produced and you get pimples or clogged pores recurrently, we would recommend controlling the excessive sebum production. You can start first by using Light emulsion day and night and cleanse your skin only in the evening with a Mineral cleanser. If needed, add Night active Control as a concentrate in the Light Emulsion as a night treatment.

The combination of Light emulsion, Night active Control, and Mineral cleanser has shown to be very effective for acne-prone skin. In November 2021, Skinome conducted a study, which involved 15 participants who represented age group 23 – 43. The study participants had oily, combination, and acne-prone skin, and two-thirds of subjects experienced sensitive skin as well. During the study, the research participants applied Light Emulsion and Night Active Control, and the treatment results were evaluated after 4 weeks. Participant self-evaluation questionnaire results indicated that their skin felt less oily when using Skinome products. The evaluation by the study assessor showed that research participants had 75% fewer acne papules/pustules, 25% fewer red pimples, and 40% fewer red areas. Finally, an instrumental analysis with an Antera 3D camera showed that the skin after 4 weeks test period was less pigmented, smoother, and had fewer irregularities, as well as an improved skin redness.

Night Active Control

Vår Night Active Control innehåller hudens endogena retinol eftersom vårt fokus är att efterlikna hudens naturliga sammansättning så mycket som möjligt. I denna formula har vi valt en något högre koncentration, 0,1 %, eftersom fet/kombinerad hud är mer tolerant än vad torrare hud är. 

Light Emulsion

Vår Light Emulsion är en ultralätt gelemulsion och innehåller ämnen som minskar talgproduktionen och reglerar mognadsprocessen hos hudens keratinocyter, vilket hjälper till att öppna porerna och minskar risken för att de blir täppta och irriterade. Den lätta emulsionsformeln har en lätt konsistens och blandningen av oljor är utvald för att passa fetare hud som är aknebenägen.

Mineral cleanser

Vår Mineral Cleanser är en rengöringscreme som effektivt tar bort smuts utan att torka ut huden. Den är effektiv men ändå mikrobiovänlig, eftersom den inte innehåller några ingredienser som kan störa hudens goda bakterier som behövs för att huden ska vara i balans. Bland de aktiva ingredienserna finns postbiotika från Lactobacillus ferment, som hjälper till att binda vatten i huden för ökad återfuktning, och för en mild utjämnande effekt använder vi lågdos BHA-syra (0,25 %) som hjälper till att ta bort döda hudceller och minska porstorleken.

* Endocrine organ: an organ that develops hormones and releases them into the bloodstream to ensure that they can travel to different tissues and organs.

References

Andrade, J., L. Wagemaker, T., Mercurio, D., & B. G. Maia Campos, P. (2018). Benefits of a dermocosmetic formulation with vitamins B3 and a B6 derivative combined with zinc-PCA for mild inflammatory acne and acne-prone skin. Jornal De Investigação Biomédica E Biofarmacêutica (Em Linha), 15(2), 214-223.


Pappas Apostolos (2009) Epidermal surface lipids, Dermato-Endocrinology, 1:2, 72-76, DOI: 10.4161/derm.1.2.7811


Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD. Exocrine gland dysfunction in MC5-R-deficient mice: Evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 1997; 91:789-98.
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Endly, D., & Miller, R. (2017). Oily Skin: A review of Treatment Options. The Journal of Clinical and Aesthetic Dermatology, 10(8), 49-55.
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Melnik BC. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clin Cosmet Investig Dermatol. 2015 Jul 15;8:371-88. doi: 10.2147/CCID.S69135. PMID: 26203267; PMCID: PMC4507494.


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Picardo M, Ottaviani M, Camera E, Mastrofrancesco A. Sebaceous gland lipids. Dermatoendocrinol. 2009 Mar;1(2):68-71. doi: 10.4161/derm.1.2.8472. PMID: 20224686; PMCID: PMC2835893.


Sakuma TH, Maibach HI. Oily skin: an overview. Skin Pharmacol Physiol. 2012;25(5):227-35. doi: 10.1159/000338978. Epub 2012 Jun 20. PMID: 22722766.


Skinome NAC Acne study, conducted November 2021.